About The Medical Condition PF4


Find the definition of the medical term PF4. PF4 defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.


PF4 Medical Condition Defined & Explained
PF4 Medical Condition

What's The Definition Of The Medical Condition PF4?

A high-molecular-weight proteoglycan-platelet factor complex which is released from blood platelets by thrombin. It acts as a mediator in the heparin-neutralizing capacity of the blood and plays a role in platelet aggregation. At high ionic strength (I=0.75), the complex dissociates into the active component (molecular weight 29,000) and the proteoglycan carrier (chondroitin 4-sulfate, molecular weight 350,000). The molecule exists in the form of a dimer consisting of 8 moles of platelet factor 4 and 2 moles of proteoglycan.

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