About The Medical Condition PKR, Protein Kinase
Find the definition of the medical term PKR, Protein Kinase. PKR, Protein Kinase defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
PKR, Protein Kinase
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What's The Definition Of The Medical Condition PKR, Protein Kinase?
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, eiF-2 kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of eIF-2, leading to the inhibition of protein synthesis. EC 2.7.10.-
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