About The Medical Condition Poly-Ig Receptor
Find the definition of the medical term Poly-Ig Receptor. Poly-Ig Receptor defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Poly-Ig Receptor
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What's The Definition Of The Medical Condition Poly-Ig Receptor?
Specialized Fc receptors (RECEPTORS, FC) for polymeric immunoglobulins, which mediate transcytosis of polymeric IMMUNOGLOBULIN A and IMMUNOGLOBULIN M into external secretions. They are found on the surfaces of epithelial cells and hepatocytes. After binding to IMMUNOGLOBULIN A, the receptor-ligand complex undergoes endocytosis, transport by vesicle, and secretion into the lumen by exocytosis. Before release, the part of the receptor (SECRETORY COMPONENT) that is bound to IMMUNOGLOBULIN A is proteolytically cleaved from its transmembrane tail. (From Rosen et al., The Dictionary of Immunology, 1989)
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