About The Medical Condition Polymeric Ig Receptor
Find the definition of the medical term Polymeric Ig Receptor. Polymeric Ig Receptor defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Polymeric Ig Receptor
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What's The Definition Of The Medical Condition Polymeric Ig Receptor?
Specialized Fc receptors (RECEPTORS, FC) for polymeric immunoglobulins, which mediate transcytosis of polymeric IMMUNOGLOBULIN A and IMMUNOGLOBULIN M into external secretions. They are found on the surfaces of epithelial cells and hepatocytes. After binding to IMMUNOGLOBULIN A, the receptor-ligand complex undergoes endocytosis, transport by vesicle, and secretion into the lumen by exocytosis. Before release, the part of the receptor (SECRETORY COMPONENT) that is bound to IMMUNOGLOBULIN A is proteolytically cleaved from its transmembrane tail. (From Rosen et al., The Dictionary of Immunology, 1989)
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