About The Medical Condition Polymyositis-Dermatomyositis

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Find the definition of the medical term Polymyositis-Dermatomyositis. Polymyositis-Dermatomyositis defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.

Polymyositis-Dermatomyositis

Polymyositis-Dermatomyositis Medical Condition Defined & Explained
Polymyositis-Dermatomyositis Medical Condition

What's The Definition Of The Medical Condition Polymyositis-Dermatomyositis?

A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)

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