About The Medical Condition Primary Lateral Sclerosis
Find the definition of the medical term Primary Lateral Sclerosis. Primary Lateral Sclerosis defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Primary Lateral Sclerosis
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What's The Definition Of The Medical Condition Primary Lateral Sclerosis?
Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvment of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
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