About The Medical Condition Progressive Multifocal Leukoencephalopathy
Find the definition of the medical term Progressive Multifocal Leukoencephalopathy. Progressive Multifocal Leukoencephalopathy defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Progressive Multifocal Leukoencephalopathy
| Progressive Multifocal Leukoencephalopathy Medical Condition |
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What's The Definition Of The Medical Condition Progressive Multifocal Leukoencephalopathy?
An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
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