About The Medical Condition Protein Kinase PKR
Find the definition of the medical term Protein Kinase PKR. Protein Kinase PKR defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Protein Kinase PKR
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What's The Definition Of The Medical Condition Protein Kinase PKR?
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, eiF-2 kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of eIF-2, leading to the inhibition of protein synthesis. EC 2.7.10.-
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