About The Medical Condition Proteins abl, Proto-Oncogene
Find the definition of the medical term Proteins abl, Proto-Oncogene. Proteins abl, Proto-Oncogene defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Proteins abl, Proto-Oncogene
| Proteins abl, Proto-Oncogene Medical Condition |
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What's The Definition Of The Medical Condition Proteins abl, Proto-Oncogene?
Non-receptor tyrosine kinases encoded by the c-abl gene. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal hematopoiesis especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation.
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