About The Medical Condition Proto-Oncogene, c-myb
Find the definition of the medical term Proto-Oncogene, c-myb. Proto-Oncogene, c-myb defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Proto-Oncogene, c-myb
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What's The Definition Of The Medical Condition Proto-Oncogene, c-myb?
Retrovirus-associated DNA sequences (v-myb) originally isolated from the avian myeloblastosis and E26 leukemia viruses. The proto-oncogene c-myb codes for a nuclear protein involved in transcriptional regulation and appears to be essential for hematopoietic cell proliferation. The human myb gene is located at 6q22-23 on the short arm of chromosome 6. This is the point of break in translocations involved in T-cell acute lymphatic leukemia and in some ovarian cancers and melanomas. (From Ibelgaufts, Dictionary of Cytokines, 1995).
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