About The Medical Condition Proto-Oncogene Products, erbA
Find the definition of the medical term Proto-Oncogene Products, erbA. Proto-Oncogene Products, erbA defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Proto-Oncogene Products, erbA
| Proto-Oncogene Products, erbA Medical Condition |
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What's The Definition Of The Medical Condition Proto-Oncogene Products, erbA?
Proteins, usually found in the nucleus, that specifically bind thyroid hormones and regulate DNA transcription. These proteins, termed c-erbA, are activated by hormones and cause differentiation of erythroid progenitor cells which irreversibly lose proliferative potential. Thus c-erbA proteins act as growth suppressors. The c-erbA proteins are encoded by at least two genes, c-erbA alpha and c-erbA beta. Each of these has two isoforms. Mutations in the ligand-binding domain of the beta form causes THYROID HORMONE RESISTANCE SYNDROME.
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