About The Medical Condition Proto-Oncogene Protein, erbB-2
Find the definition of the medical term Proto-Oncogene Protein, erbB-2. Proto-Oncogene Protein, erbB-2 defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Proto-Oncogene Protein, erbB-2
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What's The Definition Of The Medical Condition Proto-Oncogene Protein, erbB-2?
A cell surface protein-tyrosine kinase receptor that is found to be overexpressed in a significant number of adenocarcinomas. It has extensive homology to and can heterodimerize with the EGF receptor (RECEPTOR, EPIDERMAL GROWTH FACTOR), the erbB-3 receptor (RECEPTOR, ERBB-3) and the erbB-4 receptor. Activation of the erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB receptor family members. EC 2.7.11.-.
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