About The Medical Condition Proto-Oncogene Proteins, abl

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Proto-Oncogene Proteins, abl

Proto-Oncogene Proteins, abl Medical Condition Defined & Explained
Proto-Oncogene Proteins, abl Medical Condition

What's The Definition Of The Medical Condition Proto-Oncogene Proteins, abl?

Non-receptor tyrosine kinases encoded by the c-abl gene. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal hematopoiesis especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation.

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