About The Medical Condition Pyruvate Dehydrogenase Complex
Find the definition of the medical term Pyruvate Dehydrogenase Complex. Pyruvate Dehydrogenase Complex defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Pyruvate Dehydrogenase Complex
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What's The Definition Of The Medical Condition Pyruvate Dehydrogenase Complex?
A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE C (LIPOAMIDE), dihydrolipoamide acetyltransferase and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phoshorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
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