About The Medical Condition Resistance Gene-1, Multidrug
Find the definition of the medical term Resistance Gene-1, Multidrug. Resistance Gene-1, Multidrug defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Resistance Gene-1, Multidrug
| Resistance Gene-1, Multidrug Medical Condition |
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What's The Definition Of The Medical Condition Resistance Gene-1, Multidrug?
Genes responsible for multidrug resistance resulting from their overexpression in mammalian cells. Mammalian P-glycoproteins are encoded by small MDR gene familes. The human multidrug resistance 1; (MDR1); gene responds to environmental stress including various anticancer agents. It is a major determinant in the development of resistance to a large number of cancer chemotherapeutic agents. (Biochem Biophys Res Commun 1994;199(3):1428-35; Cancer Res 1994:54(6):1536-41)
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