Sandhoff Disease, Infantile Medical Condition Defined & Explained

About The Medical Condition Sandhoff Disease, Infantile

Find the definition of the medical term Sandhoff Disease, Infantile. Sandhoff Disease, Infantile defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.

Sandhoff Disease, Infantile

Sandhoff Disease, Infantile Medical Condition
What's The Definition Of The Medical Condition Sandhoff Disease, Infantile? An autosomal inherited disease caused by deficiency of the enzymes hexosaminidase A & B (see BETA-N-ACETYLHEXOSAMINIDASE) which leads to an accumulation of GM2 ganglioside and the sphingolipid globoside in neurons and other organs. Clinical manifestations resemble TAY-SACHS DISEASE, but the disease is not limited to Askenazi Jews and may feature hepatosplenomegaly. The infantile form presents in the first 4 months of life with psychomotor delay, hypotonia followed by spasticity, and cherry red spots in the macula. Rare juvenile and adult forms have been reported. (From Menkes, Textbook of Child Neurology, 5th ed, p92)

Sandhoff Disease, Infantile Medical Condition

What's The Definition Of The Medical Condition Sandhoff Disease, Infantile?

An autosomal inherited disease caused by deficiency of the enzymes hexosaminidase A & B (see BETA-N-ACETYLHEXOSAMINIDASE) which leads to an accumulation of GM2 ganglioside and the sphingolipid globoside in neurons and other organs. Clinical manifestations resemble TAY-SACHS DISEASE, but the disease is not limited to Askenazi Jews and may feature hepatosplenomegaly. The infantile form presents in the first 4 months of life with psychomotor delay, hypotonia followed by spasticity, and cherry red spots in the macula. Rare juvenile and adult forms have been reported. (From Menkes, Textbook of Child Neurology, 5th ed, p92)

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