About The Medical Condition Sclerosis, Amyotrophic Lateral
Find the definition of the medical term Sclerosis, Amyotrophic Lateral. Sclerosis, Amyotrophic Lateral defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Sclerosis, Amyotrophic Lateral
| Sclerosis, Amyotrophic Lateral Medical Condition |
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What's The Definition Of The Medical Condition Sclerosis, Amyotrophic Lateral?
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
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