About The Medical Condition TR alpha
Find the definition of the medical term TR alpha. TR alpha defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
TR alpha
| TR alpha Medical Condition |
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What's The Definition Of The Medical Condition TR alpha?
Proteins, usually found in the nucleus, that specifically bind thyroid hormones and regulate DNA transcription. These proteins, termed c-erbA, are activated by hormones and cause differentiation of erythroid progenitor cells which irreversibly lose proliferative potential. Thus c-erbA proteins act as growth suppressors. The c-erbA proteins are encoded by at least two genes, c-erbA alpha and c-erbA beta. Each of these has two isoforms. Mutations in the ligand-binding domain of the beta form causes THYROID HORMONE RESISTANCE SYNDROME.
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