About The Medical Condition Juvenile Sandhoff Disease
Find the definition of the medical term Juvenile Sandhoff Disease. Juvenile Sandhoff Disease defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Juvenile Sandhoff Disease
| Juvenile Sandhoff Disease Medical Condition |
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What's The Definition Of The Medical Condition Juvenile Sandhoff Disease?
An autosomal inherited disease caused by deficiency of the enzymes hexosaminidase A & B (see BETA-N-ACETYLHEXOSAMINIDASE) which leads to an accumulation of GM2 ganglioside and the sphingolipid globoside in neurons and other organs. Clinical manifestations resemble TAY-SACHS DISEASE, but the disease is not limited to Askenazi Jews and may feature hepatosplenomegaly. The infantile form presents in the first 4 months of life with psychomotor delay, hypotonia followed by spasticity, and cherry red spots in the macula. Rare juvenile and adult forms have been reported. (From Menkes, Textbook of Child Neurology, 5th ed, p92)
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