About The Medical Condition Nitric Oxide, Endothelium-Derived
Find the definition of the medical term Nitric Oxide, Endothelium-Derived. Nitric Oxide, Endothelium-Derived defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Nitric Oxide, Endothelium-Derived
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What's The Definition Of The Medical Condition Nitric Oxide, Endothelium-Derived?
A free radical gas produced endogenously by a variety of mammalian cells. It is synthesized from arginine by a complex reaction, catalyzed by NITRIC OXIDE SYNTHASE. Nitric oxide is endothelium-derived relaxing factor. It is released by the vascular endothelium and mediates the relaxation induced by some vasodilators such as acetylcholine and bradykinin. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic guanylate cyclase and thus elevates intracellular levels of cyclic GMP.
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