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CLINICAL PHARMACOLOGYACTION The onset of Cetacaine (benzocaine, aminobenzoate and tetracaine) produced anesthesia is rapid (approximately 30 seconds) and the duration of anesthesia is typically 30-60 minutes, when used as directed. This effect is due to the rapid onset, but short duration of action of Benzocaine coupled with the slow onset, but extended duration of Tetracaine HCl and bridged by the intermediate action of Butamben. It is believed that all of these agents act by reversibly blocking nerve conduction. Speed and duration of action is determined by the ability of the agent to be absorbed by the mucous membrane and nerve sheath and then to diffuse out, and ultimately be metabolized (primarily by plasma cholinesterases) to inert metabolites which are excreted in the urine.

Find Lowest Prices on Cetacaine Topical Anesthetic (benzocaine, aminobenzoate and tetracaine) DESCRIPTION ACTIVE INGREDIENTS Benzocaine 14.0% Butyl Aminobenzoate 2.0% Tetracaine Hydrochloride 2.0% CONTAINS Benzalkonium Chloride 0.5% Cetyl Dimethyl Ethyl Ammonium Bromide 0.005% In bland, water-soluble base.

PATIENT INFORMATION No Information Provided.

SIDE EFFECTS Hypersensitivity Reactions: Unpredictable adverse reactions (ie, hypersensitivity, including anaphylaxis) are extremely rare. Localized allergic reactions may occur after prolonged or repeated use of any aminobenzoate anesthetic. The most common adverse reaction caused by local anesthetics is contact dermatitis charaterized by erythema and pruritus that may progress to vesiculation and oozing. This occurs most commonly in patients following prolonged self-medication, which is contraindicated. If rash, urticaria, edema, or other manifestations of allergy develop during use, the drug should be discontinued. To minimize the possibility of a serious allergic reaction, Cetacaine (benzocaine, aminobenzoate and tetracaine) preparations should not be applied for prolonged periods except under continual supervision. Dehydration of the epithelium or an escharotic effect may also result from prolonged contact. DRUG INTERACTIONS No Information Provided.

WARNINGS No Information Provided. PRECAUTIONS On rare occasions, methemoglobinemia has been reported in connection with the use of benzocaine-containing products. Care should be used not to exceed a two second spray. If a patient becomes cyanotic, treat appropriately to counteract (such as with methylene blue, if medically indicated). USE IN PREGNANCY Safe use of Cetacaine (benzocaine, aminobenzoate and tetracaine) has not been established with respect to possible adverse effects upon fetal development. Therefore, Cetacaine (benzocaine, aminobenzoate and tetracaine) should not be used during early pregnancy, unless in the judgement of a physician, the potential benefits outweigh the unknown hazards. Routine precaution for the use of any topical anesthetic should be observed when Cetacaine (benzocaine, aminobenzoate and tetracaine) is used. Appropriate pediatric dosage has not been established for this product.