About The Medical Condition AlphaLbeta2, Integrin
Find the definition of the medical term AlphaLbeta2, Integrin. AlphaLbeta2, Integrin defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
AlphaLbeta2, Integrin
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What's The Definition Of The Medical Condition AlphaLbeta2, Integrin?
A heterodimer molecule widely expressed on cells of hematopoietic origin. CD11a antigen comprises the alpha chain and the CD18 antigen (ANTIGENS, CD18) the beta chain. LFA-1 is a major receptor of T-cells, B-cells, and granulocytes. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by natural killer cells and granulocytes. Intracellular adhesion molecule-1 (ICAM-1) has been defined as a ligand for LFA-1.
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