About The Medical Condition High-Molecular-Weight Kininogen

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High-Molecular-Weight Kininogen

High-Molecular-Weight Kininogen Medical Condition Defined & Explained
High-Molecular-Weight Kininogen Medical Condition

What's The Definition Of The Medical Condition High-Molecular-Weight Kininogen?

A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)

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