Diseases

Colon Cancer Screening Information

Family history of colorectal cancer

Colorectal cancer may run in families. Colon cancer risk to an individual is even higher if more than one immediate family member (parents, siblings or children) has had colorectal cancer, and/or the family member developed the cancer at a young age (less than 55). Under these circumstances, it is recommended that individuals undergo a colonoscopy every three years starting at an age that is seven to 10 years younger than the age at which the family member who developed colorectal cancer at the youngest age developed his or her cancer.If only one immediate family member developed colorectal cancer at an advanced age, the colon cancer risk to the individual is still higher than average but not as high as if two immediate family members developed colorectal cancer or if a family member developed colorectal cancer at an early age. Whether and when to perform screening colonoscopies in these individuals are best decided jointly by the individuals and their doctors.

Fecal occult blood tests (FOBT, stool testing)

Fecal occult blood tests are chemical tests that are performed on samples of stool to detect the presence of "occult" blood (amounts of blood that are so small that they cannot be seen with the naked eye). These tests usually are performed along with a digital rectal examination (DRE) that is performed by a doctor. The use of fecal occult blood tests is based on observations that slow bleeding from colon polyps or cancers can cause small amounts of blood to mix with the colonic contents. Since the small amounts of blood are not visible to the naked eye, sensitive tests are needed to detect the traces of blood in the stool. The newest form of the test is known as a fecal immunochemical, or FIT test and is even more sensitive than the older chemical or guaiac-based tests (gFOBT) for diagnosing colorectal cancer.A stool DNA test (Cologuard or FIT-DNA test) has also been developed as a screening tool. DNA testing identifies abnormal genes in stool that are characteristic of colorectal cancer from cells that have broken off from colorectal cancers and some premalignant tumors. The FIT-DNA is a stool DNA test (MT-sDNA), combining fecal DNA, fecal immunochemical test (FIT), and DNA methylation assays. (DNA methylation is a type of genetic abnormality that controls the expression of the abnormal DNA.)An individual whose stool specimen tests positive for occult blood then undergoes a colonoscopy of the entire colon to look for polyps, cancers, or other conditions that cause bleeding (such as abnormal blood vessels, diverticuli, or colitis). The majority (greater than 90%) of the polyps detected at colonoscopy can be removed painlessly and safely during the colonoscopic examination. Polyps so removed are examined later under the microscope by a pathologist to determine if they are precancerous. Individuals with precancerous polyps have a higher than average risk for developing colon cancer and are advised to return for periodic surveillance colonoscopies.Colon cancers that are detected at colonoscopy usually are removed surgically though under certain circumstances they may be removed at colonoscopy. Precancerous polyps that are too large or technically not possible to remove during colonoscopy also are removed surgically. Several studies have shown that fecal occult blood and related testing can reduce death rates (mortality) from colorectal cancer by 30%-40%.If no colonic abnormalities are found in an individual whose stool contains occult blood, consideration then is given to examining the stomach and the small intestine as sources of bleeding.

Flexible sigmoidoscopy

Flexible sigmoidoscopy utilizes a flexible sigmoidoscope, a flexible, fiberoptic viewing tube with a light at the tip. It is inserted through the anus and is used by the doctor to examine the rectum and the part of the colon adjacent to the rectum. It is a shorter version of a colonoscope. Approximately 50% of colorectal cancers and polyps are found to be within the reach of a flexible sigmoidoscope. If polyps are found during a flexible sigmoidoscopic examination, a colonoscopy to examine the entire colon is recommended to remove the polyps as well as to find and remove additional polyps in other parts of the colon. The removed polyps are examined by a pathologist under a microscope to determine if the polyps are benign, malignant, or precancerous. Individuals with precancerous polyps (adenomas and villous adenomas) have a higher than average risk of developing colon cancer, and it is recommended that they return periodically for surveillance colonoscopies.

Introduction to colon and colorectal cancer screening and surveillance

The colon, also known as the large intestine or large bowel, constitutes the last part of the digestive tract. The colon is a long, muscular tube that receives still-undigested food from the small intestine. It removes water from the undigested food, stores it and then finally eliminates it from the body as stool or feces through bowel movements. The rectum is the last part of the bowel adjacent to the anus through which stool passes to the outside.Cancer of the colon and rectum (colorectal cancer) is a type of malignant tumor arising from the inner wall of the large intestine. These malignant tumors are called cancers and can invade nearby tissue and spread to other parts of the body. Benign tumors of the colon are usually called polyps. Benign polyps do not invade nearby tissue or spread to other parts of the body like malignant tumors do. Benign polyps can be removed easily during colonoscopy and are not life-threatening. However, if benign polyps are not removed from the large intestine, they can become malignant (turn into cancer) over time. In fact, most of the cancers of the large intestine are believed to have evolved from benign polyps that are precancerous, that is, they are benign at first but later become cancerous.Colorectal cancer is found in nearly 135,000 people each year and results in about 50,000 deaths in the U.S. It is the second most common cause of death due to cancer in the U.S. after lung cancer. It is the second most common cancer in women and the third most common cancer in men. The lifetime risk for an adult American to develop colorectal cancer is 4.4%.Cancer of the colon and rectum can invade and damage adjacent tissues and organs. Cancer cells also can break away and spread to other parts of the body (such as the liver and lung) where new tumors grow. The process whereby colon cancer spreads to distant organs is called metastasis, and the new tumors are called metastases. Direct extension to or invasion of adjacent organs is a sign of a more advanced cancer, and the chance of cure in the treatment of a cancer which has directly extended into an adjacent tissue is less, even with surgery, as hidden cancer cells may also have spread elsewhere. If a colon or rectal cancer is found to have spread through the lymph channels to adjacent lymph nodes, it is increasingly likely that even the removal of the portion of the colon and lymph nodes will not cure the patient. Finding lymph node metastases suggests that undetectable microscopic cancer cells may be more likely to still be present elsewhere in the body. If the cancer spreads through the bloodstream to the liver, lungs, bones, or other organs, or through lymph channels to distant lymph nodes, then it is unlikely that a permanent cure will be obtained with treatment.Colorectal cancer is both preventable and curable when found early. Colorectal cancer is prevented by removing precancerous colon polyps. It is cured if cancerous change is found early and is surgically removed before the cancer cells spread to other parts of the body. The National Polyp Study showed in its surveillance program that individuals who had their polyps removed experienced a 90% reduction in the incidence of colorectal cancer. The few patients in the study who did develop colorectal cancer had their cancer discovered at early, surgically or endoscopically curable stages. Since most colon polyps and early cancers are silent (produce no symptoms), it is important to do screening and surveillance for colon cancer in patients without symptoms or signs of the polyps or cancers. Recommendations for cost-effective public screening and surveillance have been promulgated and endorsed by numerous societies including the U.S. Preventive Services Task Force (USPSTF), American Cancer Society, the National Cancer Institute, American College of Gastroenterology, American Medical Association, American College of Physicians, etc.

Patients with history of colon polyps

Patients with history of colon polyps often develop polyps subsequently. Therefore, periodic surveillance colonoscopies are recommended. In individuals with only precancerous polyps that are completely removed, the usual recommendation is to repeat the colonoscopy after three years. If the colonoscopy at three years shows no recurrence of polyps, then the interval between subsequent colonoscopies is extended to five years.Sometimes, doctors are not confident that all polyps have been completely removed. Examples include individuals with multiple precancerous polyps, polyps that are technically difficulty to completely excise, or less than optimal visualization of the colon due to inadequate cleansing of the colon. Under these circumstances, the decision regarding the interval between surveillance colonoscopies is best arrived at jointly between the patient and the doctor.

Patients with history of colorectal cancer

Individuals who have undergone colon cancer surgery are at higher risk of developing another colon cancer in the future. It usually is recommended that they undergo a repeat colonoscopy after six to 12 months and every three years thereafter. Early detection and treatment of future polyps and early cancers can significantly improve chances of survival.

Patients with ulcerative colitis

Patients with long-standing ulcerative colitis also have a higher risk of developing colorectal cancer. The risk of developing colon cancer is proportional to the duration of disease and to the extent of colon involved by colitis. Thus, patients with chronic ulcerative colitis involving the entire colon should have more frequent colonoscopies, including special techniques and biopsies. The biopsies are taken from the colon to look for early, microscopic precancerous changes in the cells.

Screening colonoscopy

Colonoscopies are recommended screening tools beginning at the age of 50 and thereafter every seven to 10 years if no colon polyps or cancers are found. The rationale for this recommendation is as follows:

1. Colonoscopy examines the entire colon while flexible sigmoidoscopy only examines the rectum and the colon adjacent to the rectum.
2. Approximately half of colon polyps (and colon cancers) are found in the upper colon (cecum, ascending colon, and transverse colon) and, therefore, are beyond the reach of sigmoidoscopes and would be missed by flexible sigmoidoscopy.
3. The National Polyp Study, a large, scientific study, has shown that colonoscopy with removal of all colon polyps reduces deaths from colon cancer.

Screening recommendations for individuals with average risk of colon cancer

Fecal (stool) occult blood tests (FOBT) performed on stool samples, stool DNA tests, flexible sigmoidoscopic examinations, and colonoscopy are among the recommended screening tests for individuals at average risk for developing colorectal cancer. These tests are designed to detect and to prompt removal of precancerous polyps and identify early cancers in order to decrease deaths from colorectal cancer. Most guidelines recommend beginning screening at 50 years of age for people at average risk of developing colorectal cancer. Some groups recommend that African Americans begin screening at a slightly younger age due to an increased risk.

Summary of colon cancer screening

Colon cancer is preventable and curable. Colon cancer is preventable by removing precancerous colon polyps, and it is curable if early cancer is surgically removed before cancer spreads to other parts of the body. Therefore, if screening and surveillance programs were practiced universally, there would be a major reduction in the incidence and mortality of colorectal cancer.Ongoing genetic research will help doctors better understand the genetic basis of colorectal cancer formation. Genetic blood tests and tests for premalignant cells in stool may also have a role in colorectal cancer screening. Regardless of what new screening methods become available, you should remember to discuss colon cancer screening and/or surveillance as it relates to your situation.

Surveillance recommendations for individuals with higher-than-average risk of colon cancer

Many individuals are at higher than average risk for developing colon cancer because of a family history of colon cancer, history of chronic ulcerative colitis, rare hereditary colon cancer syndromes, or a history of colon polyps or cancer. Periodic surveillance colonoscopies are recommended for these individuals to remove precancerous polyps, and /or to detect early cancers. Such testing will typically be recommended to begin at an earlier age than it will for those with average risk.

Virtual colonoscopy

Virtual colonoscopy or CT colonography is a new technique that uses an X-ray machine called a CAT or CT scanner to construct virtual images of the colon that are similar to the views of the colon obtained at colonoscopy. The virtual colonoscopic images are produced by computerized manipulation of two-dimensional images obtained by a CT scanner rather than direct observation through the colonoscope. The colon is cleaned-out using laxatives the day prior to the virtual colonoscopy examination. A tube then is inserted into the anus and is used to inject air into the colon. The CT scans then are performed, and the scans are analyzed and manipulated to form a virtual image of the colon.Properly performed virtual colonoscopy can be very good. It can even find polyps "hiding" behind folds that occasionally are missed by colonoscopy. Nevertheless, virtual colonoscopy has several limitations. They are:

1. Virtual colonoscopy cannot find small polyps (less than 5 mm in size) that are easily seen at colonoscopy.
2. Virtual colonoscopy is not as accurate as colonoscopy at finding flat cancers or premalignant lesions that are not protruding, that is, are not polyp-like.
3. Small pieces of stool can look like polyps on virtual colonoscopy and lead to a diagnosis of polyps when there are none.
4. Virtual colonoscopy cannot remove polyps. Thirty to forty percent of people have colon polyps. If polyps are found by virtual colonoscopy, then colonoscopy must be done to remove the polyps, and, therefore, many individuals having virtual colonoscopy will have to undergo a second procedure, colonoscopy.