Diseases

There is no one test that definitively indicates that someone has PPD. Therefore, health care providers diagnose this disorder by gathering comprehensive medical, family, and mental health history. Patients tend to benefit when the health care provider takes into account their client's entire life and background. This includes, but is not limited to, the person's gender, sexual orientation, cultural, religious, ethnic background, and socioeconomic status. The health care professional will also either perform a physical examination or request that the individual's primary care doctor perform one. The medical examination will usually include lab tests to evaluate the person's general health and as part of screening the individual for medical conditions that might contribute to mental health symptoms.Postpartum depression must be distinguished from what is commonly called the "baby blues," which tend to occur in most new mothers. In the brief mood problem of baby blues, symptoms like crying, sadness, irritability, anxiety, and confusion can occur. In contrast to the symptoms of PPD, the symptoms of the baby blues tend to peak around the fourth day after delivery, resolve by the 10th day and do not tend to affect the individual's ability to function.Postpartum psychosis is a psychiatric emergency that requires immediate intervention because of the danger that the sufferer might kill their baby or themselves. Postpartum psychosis usually begins within the first two weeks after delivery. Symptoms of this disorder tend to involve extremely disorganized thinking, bizarre behavior, unusual hallucinations, and delusions. Postpartum psychosis is often a symptom of bipolar disorder, also called manic depression.

Intensive nursing intervention in the form of visits to new mothers by a nurse can help prevent the development of postpartum depression.

Similar to many other mental health conditions, there is thought to be a genetic vulnerability to developing postpartum depression.Rapid changes in the levels of reproductive hormones that occur during pregnancy and after delivery are thought to be biological factors in the development of this condition. People with any history of depression or anxiety prior to the pregnancy are at risk for developing depression during the pregnancy or soon after delivery. Interestingly, men are also known to experience changes in a number of hormones during the peripartum period that can contribute to the development of PPD. Also, the stress of any medical complications as a result of the pregnancy or delivery, as well as the stress that is inherent in caring for a newborn are considerable factors.Further risk factors for developing postpartum depression include low self-esteem, low socioeconomic status, a lack of having social support before and after the birth of the baby, and marital problems, including any history of intimate partner violence.

Postpartum depression, now included in the describer of depression with peripartum onset (during pregnancy or within a month after giving birth), may be the most common problem associated with childbirth. It has been described as afflicting prominent historical figures like author/suffragist Charlotte Perkins Gilman in the 19th century. This illness is characterized by depression that a woman experiences either during pregnancy or within four weeks of giving birth, affecting about 3%-6% of women who give birth, up to 20% when only women with postpartum depression, rather than including those who are depressed during the pregnancy are counted. Peripartum depression occurs after one out of every eight deliveries in the United States, affecting about half a million women every year. Peripartum depression is also called major depression with peripartum onset. Delusional thinking after childbirth, called postpartum psychosis, affects about one in every 500 to 1,000 women.Notably, postpartum depression is not an illness that is exclusive to mothers. Fathers can experience it, as well. As with women, symptoms in men can result in fathers having difficulty caring for themselves and for their children when suffering from postpartum depression.Unfortunately, up to 50% of individuals with postpartum depression or postpartum psychosis are never detected. That can result in devastating outcomes for the patient and family. For example, postpartum psychosis is thought to have been a potential factor in Andrea Yates drowning her five children in 2001 and was explored as a factor in Susan Smith drowning her two sons in 1994.

Symptoms of postpartum depression begin either during pregnancy or within four weeks after having a baby and include the following:

• Feelings of profound sadness, emptiness, emotional numbness, irritability, or anger.
• Feelings of irritability or anger
• A tendency to withdraw from relationships with family, friends, or from activities that are usually pleasurable for the PPD sufferer
• Constant fatigue or tiredness, difficulty sleeping, overeating, or loss of appetite
• A strong sense of failure or inadequacy
• Intense concern and anxiety about the baby or a lack of interest in the baby
• Thoughts about suicide or fears of harming the baby

Postpartum psychosis occurs much more rarely and is thought to be a severe form of postpartum depression. Symptoms of that disorder include the following:

• Delusions (false beliefs)
• Hallucinations (for example, hearing voices or seeing things that are not real)
• Thoughts of harming the baby
• Severe depressive symptoms

Educational programs and support groupsTreatment of postpartum depression in men and women is similar. Both mothers and fathers with this condition have been found to greatly benefit from being educated about the illness, as well as from the support of other parents who have been in this position.PsychotherapiesPsychotherapy ("talk therapy") involves working with a trained therapist to determine methods to solve problems and cope with all forms of depression, including postpartum depression. It can be a powerful intervention and may produce, positive biochemical changes in the brain. This is a particularly important alternative to treatment with medication in women who are breastfeeding. In general, these therapies take weeks to months to complete. More intense counseling may be needed for longer when treating very severe depression or other psychiatric symptoms.Interpersonal therapy (IPT): This helps to alleviate depressive symptoms and helps the person with PPD develop more effective skills for coping with social and interpersonal relationships. IPT employs two strategies to achieve these goals.

• The first is education about the nature of depression. The therapist will emphasize that depression is a common illness and that most people can expect to get better with treatment.
• The second is defining specific problems (such as child care pressures or interpersonal conflicts). After the problems are defined, the therapist is able to help set realistic goals for solving these problems. Together, the individual with PPD and his or her therapist will use various treatment techniques to reach these goals.

Cognitive behavioral therapy (CBT): This helps to alleviate depression and reduce the likelihood it will return by helping the PPD sufferer change his or her way of thinking. In CBT, the therapist uses three techniques to accomplish these goals.

• Didactic component: This phase helps to set up positive expectations for therapy and promote cooperation.
• Cognitive component: This helps to identify the thoughts and assumptions that influence behaviors, particularly those that may predispose the person with PPD to being depressed.
• Behavioral component: This employs behavior-modification techniques to teach the individual with PPD more effective strategies for dealing with problems.

MedicationsMedication therapy for postpartum depression usually involves the use of an antidepressant medication. The major types of antidepressant medication are the selective serotonin reuptake inhibitors (SSRIs), serotonin/norepinephrine/dopamine reuptake inhibitors (NSRIs), the tricyclic antidepressants (TCAs), and the monoamine oxidase inhibitors (MAOIs). SSRI medications affect levels of serotonin in the brain. For many prescribing doctors, these medications are the first choice because of the high level of effectiveness and general safety of this group. Examples of antidepressants are listed here. The generic name is first, with the brand name in parentheses.

• Fluoxetine (Prozac)
• Sertraline (Zoloft)
• Paroxetine (Paxil)
• Fluvoxamine (Luvox)
• Citalopram (Celexa)
• Escitalopram (Lexapro)
• Vilazodone (Viibryd)
• Vortioxetine (Trintellix)

SNRIs and NDRs:

• Bupropion (Wellbutrin)
• Mirtazapine (Remeron)
• Venlafaxine (Effexor)
• Duloxetine (Cymbalta)
• Desvenlafaxine (Pristiq)
• Levomilnacipran (Fetzima)

TCAs are sometimes prescribed in severe cases of depression or when SSRIs or SNRIs are ineffective. These medications affect a number of brain chemicals (neurotransmitters), especially epinephrine and norepinephrine (also called adrenaline and noradrenaline, respectively). Examples include

• amitriptyline (Elavil),
• clomipramine (Anafranil),
• desipramine (Norpramin),
• doxepin (Adapin),
• imipramine (Tofranil), and
• nortriptyline (Pamelor).

About two-thirds of people who take antidepressant medications improve. It may take anywhere from one to six weeks of taking medication at its effective dose to notice mood improvement. It is, therefore, important not to stop taking the medication because benefits may not be seen immediately. The MAOIs are not often used since the introduction of the SSRIs. Because of the possibility of interactions, the MAOIs may not be taken with many other types of medication, and some types of foods that are high in tyramine (like aged cheeses, wines, and cured meats) must be avoided as well. Examples of MAOIs include phenelzine (Nardil) and tranylcypromine (Parnate). Atypical neuroleptic medications are often prescribed in addition to a mood-stabilizer medication in people with postpartum psychosis. Examples of atypical neuroleptics include

• aripiprazole (Abilify),
• olanzapine (Zyprexa),
• paliperidone (Invega),
• quetiapine (Seroquel),
• risperidone (Risperdal),
• ziprasidone (Geodon),
• asenapine (Saphris),
• iloperidone (Fanapt), and
• lurasidone (Latuda).

Non-neuroleptic mood-stabilizer medications are also sometimes used with a neuroleptic medication to treat people with postpartum psychosis because bipolar disorder may also be present in some patients. Examples of non-neuroleptic mood stabilizers include

• lithium (Lithium Carbonate, Lithium Citrate),
• divalproex sodium (Depakote),
• carbamazepine (Tegretol), and
• lamotrigine (Lamictal).

Women who have suffered from postpartum depression are much more likely to have depression again sometime in the future. They are also at risk for being the victim of emotional, physical, or sexual abuse, as well as for developing tobacco or other substance abuse. Children of mothers with PPD are at risk for medical emotional challenges as a result of problematic relationships with their mother and of receiving compromised care from their mother.

The current research on postpartum depression includes an increased focus on this condition in men, as well as potential natural remedies based on surges in certain brain chemicals associated with the postpartum period.

Jennifer Mudd Houghtaling Postpartum Depression Foundation200 E. Delaware Apt. 3DChicago, IL 60611Phone: 312-867-7239Email: [email protected]Kids Health -- Postpartum Depression and Caring for Your Babyhttp://kidshealth.org/parent/emotions/feelings/ppd.htmlPostpartum Education for Parentshttp://www.sbpep.orgPostpartum Progresshttp://postpartumprogress.comWomenshealth.gov helpline (English and Spanish)Phone: 800-994-9662TDD: 888-220-5446Hours: Monday through Friday, 9 a.m. to 6 p.m., EST. (closed on federal holidays)

Baby Blues Connectionhttp://www.babybluesconnection.orgToll free: 866-616-3752Online Postpartum Depression Support Grouphttp://www.ppdsupportpage.com Postpartum DadsEmail: [email protected]Postpartum Education for ParentsPO Box 261Santa Barbara, CA 93116Email: [email protected]PEP Warmline: 805-564-3888Our free 24-hour service provides confidential one-on-one support from trained volunteers who are parents just like you.Postpartum Stress Centerhttp://www.postpartumstress.comPostpartum Support InternationalEmail: [email protected]800-944-4773503-894-9453